Micro total analysis systems or lab-on-a-chip (LOC) systems have attracted considerable attention in the last decades because of their compactness, high sensitivity, low reagent consumption, and fast response time. The main advantage of LOC systems is their ability to integrate different functional devices into the same platform to simplify the biochemical detection procedure for proteomics, genomics, drug screening, and diagnostic applications. For most LOC systems, fluorescence microscopy remains the dominant detection method in conventional assays. By contrast, label-free (LF) biosensors that enable detection without requiring a fluorescence molecule offer several advantages over fluorescence microscopy and have hence gained considerable attention. Recently, we have developed LOC systems that integrates GMRF sensors and either continuous microfluidics or EWOD.